Phenol-soluble modulins – critical determinants of staphylococcal virulence
نویسندگان
چکیده
منابع مشابه
Inactivation of Staphylococcal Phenol Soluble Modulins by Serum Lipoprotein Particles
Staphylococcus aureus virulence has been associated with the production of phenol soluble modulins (PSM). PSM are known to activate, attract and lyse neutrophils. However, the functional characterizations were generally performed in the absence of human serum. Here, we demonstrate that human serum can inhibit all the previously-described activities of PSM. We observed that serum can fully block...
متن کاملPhenol-soluble modulins in staphylococci
Phenol-soluble modulins (PSMs) are amphipathic peptides produced by staphylococci that have multiple functions in pathogenesis. For example, they may function as cytotoxins and pro-inflammatory agents. Additionally, in a recent study we demonstrated that Staphylococcus aureus PSMs structure biofilms and cause dissemination during biofilm infection. Based on those results suggesting a surfactant...
متن کاملDetermination of Staphylococcal Phenol-Soluble Modulins (PSMs) by a High-Resolution HPLC-QTOF System
Phenol‐soluble modulins (PSMs) are multifunctional, amphipathic, α‐helical peptides produced by virtually all staphylococcal strains. They have recently drawn much atten‐ tion owing to the key contribution of some PSM peptides to staphylococcal virulence, in particular in highly virulent Staphylococcus aureus. High concentration of PSMs may cause cytolysis, damaging neutrophils, immune cells, r...
متن کاملInteraction of Phenol-Soluble Modulins with Phosphatidylcholine Vesicles
Several members of the staphylococcal phenol-soluble modulin (PSM) peptide family exhibit pronounced capacities to lyse eukaryotic cells, such as neutrophils, monocytes, and erythrocytes. This is commonly assumed to be due to the amphipathic, α-helical structure of PSMs, giving PSMs detergent-like characteristics and allowing for a relatively non-specific destruction of biological membranes. Ho...
متن کاملCell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading
Staphylococcus aureus produces phenol-soluble modulins (PSMs), which are amphipathic small peptides with lytic activity against mammalian cells. We previously reported that PSMα1-4 stimulate S. aureus colony spreading, the phenomenon of S. aureus colony expansion on the surface of soft agar plates, whereas δ-toxin (Hld, PSMγ) inhibits colony-spreading activity. In this study, we revealed the un...
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ژورنال
عنوان ژورنال: FEMS Microbiology Reviews
سال: 2014
ISSN: 1574-6976
DOI: 10.1111/1574-6976.12057